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Due to respiratory infections, individuals with CF have a significantly reduced life expectancy compared to healthy individuals. The reduced production of pancreatic enzymes can lead to delayed growth, and greasy stool can cause a deficiency in fat-soluble vitamins. Infertility can occur in men. Newborns often experience metabolic disorders. The presence and severity of the above-mentioned symptoms vary from patient to patient.

CF does not affect intellectual and motor skills.